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You are here:Home » Antibodies » Abs to Spectrin » Anti -Spectrin alpha chain, erythrocyte (Spectrin, alpha, erythrocytic 1, EL2, Erythroid alpha-spectrin, HPP, HS3, Spectrin alpha chain, erythrocyte, SPH3, SPTA)

Anti -Spectrin alpha chain, erythrocyte (Spectrin, alpha, erythrocytic 1, EL2, Erythroid
alpha-spectrin, HPP, HS3, Spectrin alpha chain, erythrocyte, SPH3, SPTA)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IH IF
Spectrin is the predominant component of the membrane skeleton of the red blood cell and is essential in determining shape and deformability of the membrane. It consists of 2 nonidentical subunits, alpha (MW 240,000) and beta (MW 225,000). Spectrin is present in the red cell membrane in a tetrameric or possibly higher polymeric form through head to head self association of heterodimers that are linked by actin polymers and protein 4.1 to form a 2 dimensional network.
Catalog #S5381-03C
ApplicationsSuitable for use in Immunofluorescence, ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:100 -1:500
ELISA: 1:105-1:106
Western Blot: 1:102-1:103
Immunohistochemistry: 1:10-1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9L188
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by ammonium sulfate precipitation and dialysis.
ImmunogenRecombinant alpha I spectrin (erythroid spectrin) SH3 domain
SpecificityRecognizes alpha I spectrin SH3 domain. Does not cross react with alpha II (non-erythroid) spectrin SH3 domain or recombinant human fodrin SH3 domain. Species Crossreactivity: human, rat, mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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