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You are here:Home » Antibodies » Abs to Splicing Factors » Anti -Splicing Factor 3b Subunit 4 (Splicing Factor 3b Subunit 4 49kDa, SF3B4, SF3b49, SF3b50, MGC10828, Pre-mRNA Splicing Factor SF3b 49kD Subunit, Spliceosome Associated Protein (U2 snRNP), Spliceosome-associated Protein (U2 snRNP), Spliceosome-associated Pro

Anti -Splicing Factor 3b Subunit 4 (Splicing Factor 3b Subunit 4 49kDa, SF3B4, SF3b49,
SF3b50, MGC10828, Pre-mRNA Splicing Factor SF3b 49kD Subunit, Spliceosome Associated
Protein (U2 snRNP), Spliceosome-associated Protein (U2 snRNP), Spliceosome-associated Pro

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
The SF3B4 gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.
Catalog #S5555-50G
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Cellular Localization Nuclear
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in TBS, pH 7.2, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: AAGPISERNQDAT, representing the N-Terminus of the human protein (residues 2-14), according to NP_005841.
SpecificitySpecies Crossreactivity: Crossreacts with Human. Expected to crossreact with Mouse (100% identity with immunogen), Xenopus laevis (100% identity with immunogen), Zebrafish (100% identity with immunogen) and Drosophilia melanogaster (100% identity with immunogen) due to sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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