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You are here:Home » Biochemicals » Biochem-Molecular Biology » Splitomicin (Splitomycin)

Splitomicin (Splitomycin)


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Potent inhibitor of yeast NAD+-dependent histone deacetylase Sir2p (IC50 = 60uM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering ot blocking access to the acetylated histone binding pocket.
Catalog #S5558
ApplicationsSuitable for use as a histone deacetylase inhibitor. Other applications have not been tested
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstitute with DMSO. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light and moisture.
CAS Number5690-03-9
Molecular FormulaC13H10O2
Molecular Weight198.2
FormSupplied as a white to off-white solid. Soluble in DMSO.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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