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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B

Src is a member of the Src family of protein tyrosine kinases. This kinase is expressed in different tissues of the body with the highest protein levels detected in neurons and platelets. Src can modulate the signal transduction pathways activated by several growth factors (e.g., PDGF, M-CSF and G-CSF) and integrins. Src also regulates the activity of several ion channels including the N-methyl-D-aspartate (NMDA) receptor. In addition, Src is thought to play a role in physiological/pathophysiological processes in the central nervous system. It has also been reported that mice deficient in Src develop severe osteoporosis. A total of eight membrane-associated protein tyrosine kinases have been identified within the Src gene family. Members of this group include c-Src, c-Yes, Fyn, Lck, Lyn, Blk and c-Fgr whose roles include regulation of cytoskeletal organization, cell-cell contact, DNA synthesis, proliferation and differentiation of eukaryotic cells. Elevated activity of the proto-oncogene Src has been found in many human cancers, most notably breast cancer.The highest levels of expression of the prototype member of this gene family, Src p60, are observed in platelets and in neuronal tissues. With the fact that platelets have constitutively high levels of phosphotyrosine-containing proteins suggest that Src p60 may be important for platelet homeostasis.
Catalog #	S6504-40
Applications	Suitable for use in Western Blot. Other applications not tested.
Recommended Dilutions	Western Blot: 1:1000
	Optimal dilutions to be determined by the researcher.
Positive Control	CEF cell extracts +/- Src; human platelets
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	Not Determined
Form	Supplied as a liquid in Dulbecco’s PBS (without Mg2 and Ca2), pH 7.3, 1mg/ml BSA, 0.05% sodium azide, 50% glycerol.
Purity	Purified by peptide affinity chromatography
Immunogen	Synthetic peptide corresponding to aa6-19 of human Src. Species Sequence Homology: rat; 100% and chicken; 93%
Specificity	Recognizes human Src , also known as pp60src at~60kD. Species Crossreactivity: mouse
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.