Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 1a (Signal Transducer and Activator of Transcription 1a)

Anti -STAT 1a (Signal Transducer and Activator of Transcription 1a)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B IP
STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5a, and Stat5b have a wide activation profile (1,2). STAT1 is activated by many different ligands including IFN family (IFN-a, IFN-b, IFN-g, and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1) (3). STAT1 has two forms, the 91kD STAT1a and the 84kD STAT1b, which are encoded by the same gene with splicing variant (4).
Catalog #S7969
This polyclonal antibody can be used for Western blot analysis of STAT1a expression at 11000 to 1:2000 and for immunoprecipitation at 2 to 4 ug per sample. The antibody is human and mouse reactive. Whole cell lysate from HeLa, Jurkat, or A431 cells can be used as positive control and a 91kD band can be detected. No reaction to the 84kD STAT1b.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified IgG
ImmunogenPeptide corresponding to amino acids 712 to 750 of human STAT1a (4). The sequences differ from the murine corresponding sequences by four amino acids.
SpecificityA 91kD band can be detected. No reaction to the 84kD STAT1b. Human, mouse and rat reactive.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links