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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 1, phosphorylated (Ser727) (Signal Transducer and Activator of Transcription 1, Signal Transducer and Activator of Transcription 1 91kDa, Signal Transducer and Activator of Transcription 1 alpha/beta, STAT1, STAT-1, DKFZp686B04100, ISGF-3, STAT 91, S

Anti -STAT 1, phosphorylated (Ser727) (Signal Transducer and Activator of Transcription 1,
Signal Transducer and Activator of Transcription 1 91kDa, Signal Transducer and Activator
of Transcription 1 alpha/beta, STAT1, STAT-1, DKFZp686B04100, ISGF-3, STAT 91, S

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP
STAT1 at serine 727 is one of a growing number of STATs which regulate gene transcription in response to numerous growth factors and cytokines, including the type I interferons IFN- alpha (IFNA) and IFN-beta (IFNB), regulators of anti-viral and anti-tumor responses. Research into cardiac failure, has revealed a STAT1 phospho-Ser727 dependent pathway invoking the death of cardiac myocytes through the induction of the Fas (CD95)/Fas Ligand (CD95L) system, a known key regulator of apoptosis. The relationship between STAT1 and IFN has become the focus of many malignancy studies including its influence on the cooperation between IFN and all-trans retinoic acid (ATRA) on both MCF-7 breast tumor cells and acute promyelocytic leukemia (APL) blasts (4).
Catalog #S7969-05T3
ApplicationsSuitable for use in Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10F463
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in TBS, pH 8.0, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSTAT1 peptide sequence 721-733 (phosphorylated at serine 727).
SpecificityRecognizes the phosphorylated (91kD activated) form of human signal transducer and activator of transcription 1 (STAT1) at serine 727.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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