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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 1 (Signal Transducer and Activator of Transcription 1, Signal Transducer and Activator of Transcription 1 91kDa, Signal Transducer and Activator of Transcription 1 alpha/beta, STAT1, STAT-1, DKFZp686B04100, ISGF-3, STAT 91, STAT91, Transcription Fact

Anti -STAT 1 (Signal Transducer and Activator of Transcription 1, Signal Transducer and
Activator of Transcription 1 91kDa, Signal Transducer and Activator of Transcription 1
alpha/beta, STAT1, STAT-1, DKFZp686B04100, ISGF-3, STAT 91, STAT91, Transcription Fact

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Catalog #S7969-06L
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile Tris-buffered saline, pH 7.3 (20mM Trizma base, 150mM NaCl), 0.1% BSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder from PBS, trehalose. Labeled with Biotin. Reconstitute with sterile Tris-buffered sodium chloride, pH 7.3 (20mM Trizma, 150mM sodium chloride), 0.1% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenE.coli-derived recombinant human STAT1 p91 (aa686-750).
SpecificityRecognizes the C-terminus of human STAT1 p91. No cross-reactivity with other STATs has been detected by immunoprecipitation or by Western blot. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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