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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 1, phosphorylated (Tyr701) (Signal Transducer and Activator of Transcription 1)

Anti -STAT 1, phosphorylated (Tyr701) (Signal Transducer and Activator of Transcription 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The signal transducer and activator of transcription (STAT) family of transcription factors is composed of seven family members (STATs 1, 2, 3, 4, 5A, 5B and 6) that are involved in many cell processes (apoptosis, anti-apoptosis, cell differentiation and proliferation), depending upon the cell type. STATs are activated by ligand binding to cytokine receptors and other types of receptors, whose receptors associating with Janus kinase (JAK) family members that phosphorylate STAT protein, causing it to translocate to the nucleus. In the nucleus, phosphorylated STAT protein binds to DNA and regulates the transcription of particular genes. Phosphorylation on tyrosine 701 by JAK1&2 is essential for STAT1 dimer formation, nuclear translocation and DNA binding activity.
Catalog #S7969-09C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive Control3T3-L1 adipocytes +/- Leukemia Inhibitory Factor (LIF).
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceMouse
ConcentrationAs Reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.1% sodium azide, 50% glycerol.
PurityPurified by affinity chromatography.
ImmunogenSynthetic phosphopeptide derived from the region of mouse STAT1 that contains tyrosine 701.
SpecificityRecognizes mouse STAT 1, phosphorylated (Tyr701) (Signal Transducer and Activator of Transcription 1).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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