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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 2 (Signal Transducer and Activator of Transcription 2)

Anti -STAT 2 (Signal Transducer and Activator of Transcription 2)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
STATs (signal transducers and activators of transcription) were originally discovered as two proteins (STAT 1 and 2) involved in IFN-a and IFN-g signal transduction. Since their initial identification, 5 more STAT proteins have been discovered (STAT 3, 4, 5a, 5b and 6). STATs undergo tyrosine phosphorylations in response to growth factor or cytokine signaling (in some cases mediated by JAK kinases [Janus Kinases 1, 2 and 3]), resulting in dimerization and translocation of STAT proteins to the nucleus. Phosphorylation at serine residues in certain STATs (STAT 1a, 3, 4 and 5) has also been reported, and appears to be required for the maximal activation of these proteins. By examining mutants of STAT 2, a major role in the induction of interferon alpha transcription has been described. STAT 2 is also critical to phosphorylation of STAT 1 during this induction.
Catalog #S7970-52
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionImmunoblot Analysis: 0.5-2ug/ml of this lot of antibody detected STAT2 (113kD) in HeLa cell lysates.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No5H16
HostMonkey
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide, before the addition of glycerol to 30%.
PurityPurified by Protein G affinity chromatography.
ImmunogenGST fusion protein containing aa671-806 of human STAT2.
SpecificityRecognizes human STAT2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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