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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 2, CT (Signal Transducer and Activator of Transcription 2)

Anti -STAT 2, CT (Signal Transducer and Activator of Transcription 2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
STAT (for signal transducers and activators of transcription) proteins can be selectively phosphorylated on tyrosine residues by Jak family kinases and some receptors with tyrosine kinase activity. The STAT proteins are highly conserved in their amino termini, but have divergent carboxy termini, which are thought to be essential for their selective activity. Seven STAT proteins have been described (STAT1-a, STAT1-ß, STAT2, STAT3, STAT4, STAT5, and STAT6) and range in molecular weight from 84113kDa. Interferon-a promotes phosphorylation of STAT1 and STAT2, which then form heterodimers that interact with the 48kDa DNA binding protein ISGF3 (interferon-stimulated growth factor 3). This complex moves to the nucleus where it binds to interferon-stimulated response elements and activates transcription of specific genes. In contrast to interferon-a signaling, interferon-g only induces phosphorylation of STAT1a or ß. Phosphorylated STAT1 monomers then form homodimers via the interaction of SH2 domains containing phosphotyrosine residues. These STAT1 homodimers have DNA binding activity. In summary, STAT proteins may be involved in the intracellular signaling of many cytokines and growth factors via the activation of gene expression. Immunogen: GST fusion protein containing amino acids 671806 of human STAT2 expressed in E. coli.
Catalog #S7970-75
Applications Included Positive Antigen Control for Western Immunoblot Analysis: Jurkat cell lysate. Use 20ug per lane.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration1mg/ml
FormSupplied as a liquid in 0.1M Tris-Glycine buffer, pH 7.4
PurityProtein A affinity purified IgG
ImmunogenGST fusion protein containing amino acids 671806 of human STAT2 expressed in E. coli.
SpecificityRecognizes the 113kDa STAT2 protein. Crossreacts with mouse.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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