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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 2, phosphorlated (Tyr689) (Signal Transducer and Activator of Transcription 2)

Anti -STAT 2, phosphorlated (Tyr689) (Signal Transducer and Activator of Transcription 2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B FC
STAT2 (signal transducer and activator of transcription #2) is a 98kD member of the STAT family of cytoplasmic transcription factors. STAT members generally mediate cytokine, growth factor and hormone receptor signal transduction. STAT2 is associated with type I ( and --) interferon signaling. All STATs contain an N-terminal oligomerization domain, a DNA-binding domain, and an SH2-association region. STAT2 is phosphorylated at Y689 by receptor-associated Janus kinases (JAKs) leading to STAT2 dimerization and subsequent translocation to the nucleus to activate gene transcription.
Catalog #S7970-80E
ApplicationsSuitable for use in Western Blot and Flow Cytometry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5ug/ml
Flow Cytometry: 2.5ug/10e6 cells.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.2mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose, 0.1% sodium azide. Reconstitute with 250ul sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenPhosphopeptide containing Y689 site of human STAT2
SpecificityRecognizes human phospho-STAT2 (Tyr689).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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