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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 2, phosphorlated (Tyr689) (Signal Transducer and Activator of Transcription 2) (Carboxyfluorescein)

Anti -STAT 2, phosphorlated (Tyr689) (Signal Transducer and Activator of Transcription 2)
(Carboxyfluorescein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified FC
Signal Transducer and Activator of Transcription 2 (STAT2) is a 98kD member of the STAT family of cytoplasmic transcription factors. STAT members generally mediate cytokine, growth factor and hormone receptor signal transduction. STAT2 is associated with type I (a and b--) interferon signaling. All STATs contain an N-terminal oligomerization domain, a DNA-binding domain, and an SH2-association region. STAT2 is phosphorylated at Y689 by receptor-associated Janus kinases (JAKs) leading to STAT2 dimerization and subsequent translocation to the nucleus to activate gene transcription.
Catalog #S7970-80F
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionsFlow Cytometry: Use 10ul to label 5x10e5 cells.
Excitation: 488nm
Emission: 515-545nm
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Protect from light.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNo Determined
FormSupplied as a liquid in PBS, 0.1% sodium. Labeled with Carboxyfluorescein.
PurityPurified by Protein A affinity chromatography.
ImmunogenPhosphopeptide containing Y689 site of human STAT2
SpecificityRecognizes human STAT 2 phosphoryated at Tyr689.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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