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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 4 (Signal Transducer and Activator of Transcription 4)

Anti -STAT 4 (Signal Transducer and Activator of Transcription 4)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant E B IP IH IC FC
Janus family tyrosine kinases (Jaks) and signal transducers and activators of transcription (STATs) are involved in mediating gene expression in response to cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the STATs. Activated STATs, then, translocate to the nucleus to mediate gene transcription. Stat4 is a signal transducer and activator of transcription. It is specifically involoved in IL-12 signaling. Human Stat4 is phosphorylated on serine 721, tyrosine 355, and tyrosine 693. Phosphorylation at tyrosine leads to induces interaction with Stat3. While, Stat4 phospholyation at serine is linked to requirement for maximal transcriptional activity.
Catalog #S7972-06A
ApplicationsSuitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionsFlow Cytometry: 1:80
Western Blot: 1:1000-1:10,000
Immunoprecipitation: 1:20
Immunohistochemistry: 1:100-1:250
Immunocytochemistry: 1:100-1:250
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E560
HostRabbit
SourceHuman
ConcentrationNot Deterrmined
FormSupplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues surrounding serine 721 of human STAT 4.
SpecificityRecognizes human STAT 4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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