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You are here:Home » Antibodies » Antibodies-Transcription Factors, STAT » Anti -STAT 5, pan (Signal Transducer and Activator of Transcription 5, pan)

Anti -STAT 5, pan (Signal Transducer and Activator of Transcription 5, pan)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
STATs were originally identified as two novel DNA-binding proteins (STAT1 and STAT2) which were found to play central roles in interferon IFNa-and IFNg-regulated gene expression. Following the identification of these first two family members, five additional mammalian STAT proteins have been cloned, and characterized including: STAT3, STAT4, STAT5a, STAT5b, and STAT6. More recently a putative Drosophila STAT protein termed D-STAT or Marelle was described. All STAT proteins share several conserved structural and functional domains. In unstimulated cells, STAT proteins exist largely in the cytoplasm as latent transcription factors. In response to treatment of target cells with cytokines or in some cases growth factors, STATs undergo tyrosine phosphorylation, homo-or heterodimerization, nuclear translocation, and DNA binding which results in transcriptional activation of distinct target genes.
Catalog #S7972-07B
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.1-1ug/ml
Western Blot: 1-3ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No3G277
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenA peptide corresponding to a conserved amino acid sequence found near the carboxy-terminus of murine STAT5. The peptide encompasses the conserved C-terminal tyrosine phosphorylation site (Y-694) of murine STAT5.
SpecificityReacts specifically with both mouse STAT5a and STAT5b proteins. Can be used to detect both the un-phosphorylated and phosphorylated forms of STAT5. Does not crossreact with other endogenous STAT isoforms. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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