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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 5, phosphorylated (Tyr694) (Signal Transducer and Activator of Transcription 5, STAT5, Mammary Gland Factor, MGF, Signal Transducer and Activator of Transcription 5A, STAT5A, STAT5B, Transcription Factor STAT5A)

Anti -STAT 5, phosphorylated (Tyr694) (Signal Transducer and Activator of Transcription 5,
STAT5, Mammary Gland Factor, MGF, Signal Transducer and Activator of Transcription 5A,
STAT5A, STAT5B, Transcription Factor STAT5A)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP FC IF
Stat5 is activated in response to a wide variety of ligands including IL-2, GM-CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation (1,2). This phosphorylation is mediated by Src upon erythropoietin stimulation (3). Stat5 is constitutively active in some leukemic cell types (4). Phosphorylated Stat5 is found in some endothelial cells treated with IL-3, which suggests its involvement in angiogenesis and cell motility (5). Stat5a and Stat5b are independently regulated and activated in various cell types. For instance, interferon treatment predominantly activates Stat5a in U-937 cells and Stat5b in HeLa cells (6).
Catalog #S7972-07C2
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, Immunofluorescence (IC) and Flow Cytometry. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No10E49
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied in liquid 10mM HEPES, pH 7.5, 150mM NaCl, 100ug/ml BSA, 50% glycerol, 0.02% sodium azide.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues surrounding Tyr694 of human Stat5a protein (KLH-coupled).
SpecificityRecognizes human Phospho-Stat5 (Tyr694). Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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