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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 5A, phosphorylated (Ser780) (Signal Transducer and Activator of Transcription 5A, STAT5A, STAT5, Mammary Gland Factor, MGF)

Anti -STAT 5A, phosphorylated (Ser780) (Signal Transducer and Activator of Transcription
5A, STAT5A, STAT5, Mammary Gland Factor, MGF)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5a, and Stat5b have a wide activation profile. Both Stat5a and Stat5b regulate interleukin-7 induced B-cell precursor expansion. Activation of the protein in myeloma and lymphoma associated with a TEL:JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. Human STAT5A gene is mapped to chromosome 17q11.2.
Catalog #S7972-08D
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlHeLa cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human STAT5A around the phosphorylation site of serine 780 (R-L-SP-P-P).
SpecificityRecognizes human STAT5A when phosphorylated at Ser780. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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