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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 5B (Signal Transducer and Activator of Transcription 5b, OTTMUSP00000002051, OTTMUSP00000002050, RP23-279L23.3, Transcription Factor STAT5B, Mammary Gland Factor STAT5B) (Azide Free)

Anti -STAT 5B (Signal Transducer and Activator of Transcription 5b, OTTMUSP00000002051,
OTTMUSP00000002050, RP23-279L23.3, Transcription Factor STAT5B, Mammary Gland Factor
STAT5B) (Azide Free)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IF
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq]
Catalog #S7972-15E
ApplicationsSuitable for use in ELISA, Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
ELISA: 1ug/ml-3ng/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No11C808
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).
PurityPurified by ammonium sulfate precipitation.
ImmunogenFull-length, recombinant protein corresponding to aa1-391 of human STAT5B with GST tag. (MW of GST tag alone is 26kD)
SpecificityRecognizes human STAT5B.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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