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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 5b (Signal Transducer and Activator of Transcription 5b)

Anti -STAT 5b (Signal Transducer and Activator of Transcription 5b)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Signal Transduction and Activator of Transcription 5B (STAT5B) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL22, IL6, IFN ). Upon cytokine activation, STAT5B is phosphorylated and translocates to the nucleus where it binds to the DNA consensus site TTCN3GAA and activates transcription of specific genes. STAT5B shares 93% amino acid identity with STAT5A. STAT5B is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival.
Catalog #S7972-15H
HybridomaProduced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of human STAT5B (aa 777-787; Accession number NP_036580).
ApplicationsWestern Blot: 0.5ug/ml
Optimal dilutions should be determined by each laboratory for each application.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No7H183
HostMouse
ConcentrationAs reported
FormSupplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic STAT5B Peptide (aa777-787)
SpecificityDetects human STAT5B.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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