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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 6 (STAT6B, STAT6C, D12S1644, IL-4-STAT, interleukin 4 induced STAT, Signal Transducer and Activator of Transcription 6)

Anti -STAT 6 (STAT6B, STAT6C, D12S1644, IL-4-STAT, interleukin 4 induced STAT, Signal
Transducer and Activator of Transcription 6)


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Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP IC FC
Janus family tyrosine kinases (Jaks) and signal transducers and activators of transcription (STATs) are involved in mediating gene expression in response to cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the STATs. Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Stat6 is tyrosine phosphorylated in response to cellular interaction with IL-3 and IL-4 (3,4).
Catalog #S7972-25C
ApplicationsSuitable for use in Flow Cytometry, Western Blotting, Immunoprecipitation,
Immunocytochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:10
Western Blotting: 1:5,000 (100kD)
Immunocytochemistry: 1:250-500
Immunoprecipitation: 1:30 1ug/mg of total cell protein (~10e7 cells)
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No6k384
ConcentrationNot determined
FormSupplied as a liqud.
ImmunogenA synthetic peptide corresponding to residues in C-terminus of human Stat-6.
SpecificityRecognizes human Stat-6. Does not cross-react with other Stat family members.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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