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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 6 (STAT6B, STAT6C, D12S1644, IL-4-STAT, interleukin 4 induced STAT, Signal Transducer and Activator of Transcription 6)

Anti -STAT 6 (STAT6B, STAT6C, D12S1644, IL-4-STAT, interleukin 4 induced STAT, Signal
Transducer and Activator of Transcription 6)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
When activated by Janus kinases Stat6 is transported to the nucleus where it regulates cytokineinduced gene expression. Required for responsiveness to IL-4 and IL-13 (1,2), Stat6 is activated via phosphorylation at tyrosine 641 (3,4). In addition to its role in mediating IL-
4 responses, Stat6 is activated in B cell lines by IFN-alpha, where it forms transcriptionally active complexes with Stat2 and p48 protein (5,6). Protein phosphatase 2A is also involved in regulation of IL-4-mediated Stat6 signaling (7).
Catalog #S7972-42A
ApplicationsSuitable for use in Western Blotting, Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Immunoprecipitation: 1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (30-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol
PurityProtein A and peptide affinity chromatography
ImmunogenSynthetic peptide (KLH coupled) corresponding to residues surrounding amino acid 620 of human Stat6
SpecificityDetects endogenous levels of total Stat6
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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