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You are here:Home » Antibodies » Abs to Transcription Factors, STAT » Anti -STAT 6 (STAT6B, STAT6C, D12S1644, IL-4-STAT, interleukin 4 induced STAT, Signal Transducer and Activator of Transcription 6)

Anti -STAT 6 (STAT6B, STAT6C, D12S1644, IL-4-STAT, interleukin 4 induced STAT, Signal
Transducer and Activator of Transcription 6)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IH
STAT6 is a latent cytosolic transcription factor which becomes activated following phosphorylation by JAK1 and JAK3, in response to IL-4 and IL-13. Upon activation, STAT6 proteins form homodimers which translocate to the nucleus. STAT6 is critical for the expression of many IL-4 and IL-13 responsive genes, including class II major histocompatibility molecules, CD23 and IL-1Ra. It also plays an important role in Th2 differentiation, IgE class switching and inflammation.
Catalog #S7972-42D
ApplicationsSuitable for use in Western Blot. Immunoprecipitation and Immunohistochemistry (Frozen). Other applications not tested.
Recommended DilutionWestern Blot: 1: 1.000-1: 10,000
Immunoprecipitation: 1-4ug/mg protein
Optimal dilution determined by the researcher.
Recommended Secondary ReagentsSheep anti rabbit IgG: HRP
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
FormSupplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to a 40 amino acid sequence within human STAT6.
SpecificitySpecific for human STAT6 (signal transducer and activator of transcription 6).
Species Cross ReactivityMouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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