Stathmin-2 (STMN2), also known as superior cervical ganglion 10 protein (SCG10), is a 19kD microtubule-destabilizing protein that is preferentially expressed in neurons. It promotes neuronal proliferation and migration as well as neurite outgrowth. Stathmin-2 contains a membrane attachment region aa1-26, a regulatory domain aa39-96, and an overlapping coiled-coil domain aa75-179. It is subject to phosphorylation of multiple serines within the regulatory domain. Within aa26-179, human Stathmin-2 shares 100% and 99% aa sequence identity with mouse and rat Stathmin-2.
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