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You are here:Home » Antibodies » Abs to 14-3-3 » Anti -SFN, NT (14-3-3 Protein sigma, Epithelial Cell Marker Protein 1, Stratifin, HME1)

Anti -SFN, NT (14-3-3 Protein sigma, Epithelial Cell Marker Protein 1, Stratifin, HME1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH
Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. As 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. 14-3-3 sigma may be required for Raf-1 kinase activity and phosphorylation, among many other functions.
Catalog #S7973-69H
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 1:250
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceSheep
ConcentrationNot determined
FormSupplied as a liquid , 0.09% sodium azide.
PuritySerum
ImmunogenSynthetic peptide MERASLIQKAC corresponding to acetylated N-terminal sequence of sheep 14-3-3 sigma.
SpecificityRecognizes 14-3-3 sigma in all mammals. Species sequence homology: Bovine, chicken, human, mammal, mouse, rabbit, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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