Stromal Cell Derived Factor 1alpha, aa1-68, Recombinant, Mouse (SDF1 alpha, SDF1a, SDF-1a,
Chemokine (C-X-C Motif) Ligand 12, CXCL12, hIRH, Pre-B cell Growth-stimulating Factor,
PBSF, SCYB12, TLSF-a, TPAR1)
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| Chemokine SDF-1 is highly conserved among species and belongs to a large family of small, structurally related cytokines. It is a chemoattractant for T lymphocytes, monocytes, and hemopoietic stem cells and is constitutively expressed in bone-marrow-derived stromal cells. Recent reports indicate that SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. SDF-1a and SDF-1b, are generated by alternative RNA splicing of transcripts encoded by a single gene. SDF-1a differs from SDF-1b by four C-terminal amino acid residues absent in SDF-1a. As yet, no functional differences have been reported. | | | Catalog # | S7975-51 | | Stromal Cell-Derived Factor-1a (SDF1a) is a recently discovered protein belonging to the a-chemokine (C-X-C) family of cytokines. Murine SDF1a is an 7.9kD protein containing 68 amino acid residues. | | Source | E. coli | | Form | Sterile-filtered solution was lyophilized from 10mM acetic acid. | | Purity | 98% by SDS-PAGE and HPLC analyses. | | Endotoxin | 0.1 ng/ug | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile distilled water and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Biological Activity | Determined by its ability to chemoattract human peripheral blood monocytes using a concentration of 50-100ng/ml. | | Concentration Range for most in vitro applications | 0.1-1 mg/ml | | AA Sequence | KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK | | Country of Origin | USA | | Molecular Weight | 7.9kD | | Source | Human | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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