Anti -Structural Maintenance of Chromosomes 1 (SMC1, bK268H5, bK268H5.5, CDLS2,
DKFZp686L19178, DXhXs423e, DXS423E, FLJ43748, KIAA0178, MGC138332, OTTHUMP00000061876,
RP6-29D12.1, Sb1.8, SB1.8/DXS423E Protein, Segregation of Mitotic Chromosomes 1,
Segregation o
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP IF |
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| SMC1 is involved in chromosome cohesion during cell cycle and in DNA repair. It is a central component of the cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, SMC1 works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint. | | | Catalog # | S7980-01A2 | | Applications | Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Immunofluoresence: 1:200-1:800 | | Immunoprecipitation: 1-4ug/mg of lysate | | Western Blot: 1:1000-1:10,000 | | Optimal dilutions to be determined by the researcher. | | Positive Control | HeLa Nuclear Extract | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in Tris-citrate/phosphate pH 7.5, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Epitope maps to a region between residue 1175 and the C-terminus of human Structural Maintenance of Chromosomes-1. NP_006297.2 (Gene ID 8243). | | Cellular Localization | Nuclear | | Specificity | Recognizes human SMC1 at ~160kD. | | Species Crossreactivity | Mouse and Xenopus. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Structural Maintenance of Chromosomes 1 (SMC1, bK268H5, bK268H5.5, CDLS2, DKFZp686L19178, DXhXs423e, DXS423E, FLJ43748, KIAA0178, MGC138332, OTTHUMP00000061876, RP6-29D12.1, Sb1.8, SB1.8/DXS423E Protein, Segregation of Mitotic Chromosomes 1, Segregation o |
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