Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -Structural Maintenance of Chromosomes 1 (SMC1, bK268H5, bK268H5.5, CDLS2, DKFZp686L19178, DXhXs423e, DXS423E, FLJ43748, KIAA0178, MGC138332, OTTHUMP00000061876, RP6-29D12.1, Sb1.8, SB1.8/DXS423E Protein, Segregation of Mitotic Chromosomes 1, Segregation o

Anti -Structural Maintenance of Chromosomes 1 (SMC1, bK268H5, bK268H5.5, CDLS2,
DKFZp686L19178, DXhXs423e, DXS423E, FLJ43748, KIAA0178, MGC138332, OTTHUMP00000061876,
RP6-29D12.1, Sb1.8, SB1.8/DXS423E Protein, Segregation of Mitotic Chromosomes 1,
Segregation o

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IP IC IF
SMC1 is involved in chromosome cohesion during cell cycle and in DNA repair. It is a central component of the cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, SMC1 works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint.
Catalog #S7980-01A2
ApplicationsSuitable for use in Immunofluorescence/Immunocytochemistry, ELISA, Western Blot, Immunoprecipitation and Proximity Ligation Assay. Other applications not tested.
Recommended DilutionImmunofluoresence (IC): 1:200-1:800
Immunoprecipitation: 1:10-1:500
Western Blot: 1:1000-1:10,000
ELISA: 1:100-1:2000
Proximity Ligation Assay: 1:1000-1:10,000
Optimal dilutions to be determined by the researcher.
Positive Control HeLa Nuclear Extract
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in Tris-citrate/phosphate pH 7.5, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenMaps to a region between residue 1175 and the C-terminus of human Structural Maintenance of Chromosomes-1. (NP_006297.2, Gene ID 8243)
Cellular LocalizationNuclear
SpecificityRecognizes human SMC1 at ~160kD.
Species CrossreactivityMouse and Xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links