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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -Structural Maintenance of Chromosomes 1 (SMC1, bK268H5, bK268H5.5, CDLS2, DKFZp686L19178, DXhXs423e, DXS423E, FLJ43748, KIAA0178, MGC138332, OTTHUMP00000061876, RP6-29D12.1, Sb1.8, SB1.8/DXS423E Protein, Segregation of Mitotic Chromosomes 1, Segregation o

Anti -Structural Maintenance of Chromosomes 1 (SMC1, bK268H5, bK268H5.5, CDLS2,
DKFZp686L19178, DXhXs423e, DXS423E, FLJ43748, KIAA0178, MGC138332, OTTHUMP00000061876,
RP6-29D12.1, Sb1.8, SB1.8/DXS423E Protein, Segregation of Mitotic Chromosomes 1,
Segregation o

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit IP
SMC1 is involved in chromosome cohesion during cell cycle and in DNA repair. It is a central component of the cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint.
Catalog #S7980-01A3
ApplicationsSuitable for use in Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormAs reported
PurityAs reported
ImmunogenA synthetic peptide, which represented a portion of human Structural Maintenance of Chromosomes-1 encoded within exon 26 (LocusLink ID 8243).
SpecificityThis antibody is specific for SMC1. Species Crossreactivity: human SMC1. Other species have not been tested. Mouse, rat and bovine expected based upon sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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