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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -Structural Maintenance of Chromosomes 1, phosphorylated (Ser957) (SMC1, bK268H5, bK268H5.5, CDLS2, DKFZp686L19178, DXhXs423e, DXS423E, FLJ43748, KIAA0178, MGC138332, OTTHUMP00000061876, RP6-29D12.1, Sb1.8, SB1.8/DXS423E Protein, Segregation of Mitotic Chr

Anti -Structural Maintenance of Chromosomes 1, phosphorylated (Ser957) (SMC1, bK268H5,
bK268H5.5, CDLS2, DKFZp686L19178, DXhXs423e, DXS423E, FLJ43748, KIAA0178, MGC138332,
OTTHUMP00000061876, RP6-29D12.1, Sb1.8, SB1.8/DXS423E Protein, Segregation of Mitotic Chr

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Involved in chromosome cohesion during cell cycle and in DNA repair and is a central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. SMC1 is involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint.
Catalog #S7980-01E1
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormTris-citrate/phosphate [pH7-8]
PurityPurified by immunoaffinity chromatography.
ImmunogenRabbits were immunized with a phosphorylated synthetic peptide, which represented the portion of human Structural Maintenance of Chromosomes-1; (LocusLink ID 8243) around Serine 957, conjugated to KLH. After multiple immunizations in Freund's adjuvant, serum was collected. Antibodies that were not phospho-specific were removed by solid phase absorption. Antibodies specific for SMC1 pSer957 were affinity purified using the phosphopeptide immobilized on solid support.
SpecificityReacts with human SMC1 phosphoSerine 957 Species Crossreactivity: reacts with human SMC1 phosphoSerine 957. Other species have not been tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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