Anti -Structural Maintenance of Chromosomes 1 (SMC1, Structural Maintenance of Chromosomes
Protein 1A, SMC Protein 1A, SMC-1-alpha, SMC1alpha, SMC1A, SMC-1A, CDLS2, DKFZp686L19178,
DXS423E, KIAA0178, MGC138332, Sb1.8, SMC1L1, SMCB)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
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| SMC1 is a member of the structural maintenance of chromosomes family. It was originally identified in Saccharomyces sereviciae as a component of cohesin, a protein complex that is required for maintenance of sister chromatid cohesion. SMC1 was also reported to be present in a biochemically defined mammalian protein complex, called RC-1, which promotes DNA recombination. The protein was recently shown to be a target of the ATM kinase with phosphorylation of Ser 957 and Ser 966 of SMC1 occurring in an ATM-dependent manner after ionizing irradiation. The protein thus participates in cellular responses to DNA damage. Human SMC1 gene is localized on chromosomal region Xp11.22-p11.21. | | | Catalog # | S7980-01T | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Immunohistochemistry (paraffin): 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Positive Control | K562 cells | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic non-phosphopeptide corresponding to human SMC1 around the phosphorylation site of serine 957 (G-S-SP-Q-G). | | Specificity | Recognizes human SMC1. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Structural Maintenance of Chromosomes 1 (SMC1, Structural Maintenance of Chromosomes Protein 1A, SMC Protein 1A, SMC-1-alpha, SMC1alpha, SMC1A, SMC-1A, CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, Sb1.8, SMC1L1, SMCB) |
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