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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -Structural Maintenance of Chromosomes 1, phosphorylated (Ser957) (SMC1, Structural Maintenance of Chromosomes Protein 1A, SMC Protein 1A, SMC-1-alpha, SMC1alpha, SMC1A, SMC-1A, CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, Sb1.8, SMC1L1, SMCB)

Anti -Structural Maintenance of Chromosomes 1, phosphorylated (Ser957) (SMC1, Structural
Maintenance of Chromosomes Protein 1A, SMC Protein 1A, SMC-1-alpha, SMC1alpha, SMC1A,
SMC-1A, CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, Sb1.8, SMC1L1, SMCB)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
SMC1 is a member of the structural maintenance of chromosomes family. It was originally identified in Saccharomyces sereviciae as a component of cohesin, a protein complex that is required for maintenance of sister chromatid cohesion. SMC1 was also reported to be present in a biochemically defined mammalian protein complex, called RC-1, which promotes DNA recombination. The protein was recently shown to be a target of the ATM kinase with phosphorylation of Ser 957 and Ser 966 of SMC1 occurring in an ATM-dependent manner after ionizing irradiation. The protein thus participates in cellular responses to DNA damage. Human SMC1 gene is localized on chromosomal region Xp11.22-p11.21.
Catalog #S7980-01U
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlK562 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human SMC1 around the phosphorylation site of serine 957 (G-S-SP-Q-G).
SpecificityRecognizes human SMC1 when phosphorylated at Ser957. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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