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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -Structural Maintenance of Chromosomes 3, phosphorylated (Ser383) (Structural Maintenance of Chromosome 3, SMC3, SMC-3, BAM, Bamacan, Basement Membrane-associated Chondroitin Proteoglycan, BMH, Chondroitin Sulfate Proteoglycan 6, CSPG6, Chromosome-associat

Anti -Structural Maintenance of Chromosomes 3, phosphorylated (Ser383) (Structural
Maintenance of Chromosome 3, SMC3, SMC-3, BAM, Bamacan, Basement Membrane-associated
Chondroitin Proteoglycan, BMH, Chondroitin Sulfate Proteoglycan 6, CSPG6,
Chromosome-associat

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IP
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosome movement.
Catalog #S7982-03B
ApplicationsSuitable for use in Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormAs reported
PuritySerum
ImmunogenRabbits were immunized with a phosphorylated synthetic peptide, which represented a portion of human Structural Maintenance of Chromosomes-3 (LocusLink ID 9126) around Serine 383, conjugated to KLH. After multiple immunizations in Freund's adjuvant, serum was collected. Antibodies that were not phospho-specific were removed by solid phase absorption. Antibodies specific for SMC3 pSer383 were affinity purified using the phosphopeptide immobilized on solid support.
SpecificityReacts with human SMC3 phosphoSerine 383. Other species have not been tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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