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You are here:Home » Antibodies » Antibodies-Cell Division Cycle (CDC) » Anti -Structural Maintenance of Chromosomes 4 (Structural Maintenance of Chromosomes Protein 4, SMC Protein 4, SMC4, SMC-4, Chromosome-associated Polypeptide C, CAPC, hCAP-C, SMC4L1, XCAP-C Homolog)

Anti -Structural Maintenance of Chromosomes 4 (Structural Maintenance of Chromosomes
Protein 4, SMC Protein 4, SMC4, SMC-4, Chromosome-associated Polypeptide C, CAPC, hCAP-C,
SMC4L1, XCAP-C Homolog)


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Clone Host Grade Applications
Monoclonal Rabbit Purified B IP
Structural maintenance of chromosomes 2 (SMC2) and 4 (SMC4) proteins are subunits of the condensin complex, which enables chromosome condensation and maintains the compaction of chromosomes as they separate to opposite poles during anaphase (1-3). In addition to regulating chromosome condensation, condensin is a general regulator of chromosome architecture and may function to regulate gene expression and DNA repair. SMC proteins contain a hallmark bipartite ATPase domain of the ABC ATPase superfamily, which consists of an N-terminal Walker A motif nucleotide-binding domain and C-terminal Walker B motif catalytic domain that interact to form a functional ATPase (1-3). The two ATPase domains are connected
by two coiled coil domains separated by a central hinge region that facilitates protein-protein interactions between partnering SMC proteins. In the case of the condensin complex, SMC2 and SMC4 interact to form a functional ATPase required for chromatin condensation; however, the
mechanism by which this ATPase activity regulates chromsome architecture is still being determined. In addition to SMC proteins, condensin contains three auxiliary subunits, which function to regulate condensin ATPase activity. Higher eukaryotes contain two distinct condensin complexes (condensin I and II), both of which contain SMC2 and SMC4 (1-3). Condensin I also contains the auxiliary subunits CAP-D2, CAP-G and CAP-H, while condensin II contains the related auxiliary proteins CAP-D3, CAP-G2 and CAPH2. The two condensin complexes show different localization patterns during the cell cycle and on chromosomes and both are required for a successful mitosis, suggesting distinct functions for each complex (1-3).
Catalog #S7983-03
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000 Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight.
Immunoprecipitation: 1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No11C1074
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, less than 0.02% sodium azide, 50% glycerol.
ImmunogenSynthetic peptide corresponding to residues surrounding Tyr95 of human SMC4.
SpecificityRecognizes endogenous levels of total SMC4. Species Crossreactivity: bovine, monkey, mouse, rat, xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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