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You are here:Home » Antibodies » Abs to Substance P » Anti -Substance P (NK, Neurokinin)

Anti -Substance P (NK, Neurokinin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IH
The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.
Catalog #S8000-01B
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionsELISA: 1:10,000
Immunohistochemistry (Vibratome): 1:500-1:1000
Immunohistochemistry (Frozen): 1:300
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone NoSP-DE4-21
HostMouse
SourceHuman
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, pH 7.2, 0.1M glycine. Reconstitute with 10ul sterile ddH2O.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding RPRPQQFFGLM from human Substance P.
SpecificityRecognizes human Substance P. No crossreactivity with related tachykinins (human Neurokinin A, Neurokinin B, and Kassinin). Species Crossreactivity: mouse, rat and guinea pig
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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