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You are here:Home » Antibodies » Abs to Substance P » Anti -Substance P (NK, Neurokinin)

Anti -Substance P (NK, Neurokinin)

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Specifications

Clone Host Grade Applications
Polyclonal Guinea pig Serum IH
Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapse. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
Catalog #S8000-02D
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Frozen): 1:400-1:800 using Immunoflourescence. Incubate overnight at 4ºC.
Optimal dilutions to be determined by the researcher.
Positive ControlCryostat sections of rat colon
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGuinea pig
ConcentrationNot determined
FormSupplied as a lyophilized powder. Reconstitute in 50-100ul sterile ddH2O. Dilute further in 0.1M PBS, 1% BSA, 0.1% sodium azide.
PuritySerum
ImmunogenSubstance P conjugated to BSA.
SpecificityRecognizes Substance P. Species Crossreactivity: Rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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