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Specifications

Clone Host Grade Applications Polyclonal Rabbit Serum IH IF

Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions. Substance P-containing tumors arising in the ileum are often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, bronchoconstriction and sudden drops in blood pressure. Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide.
Catalog #	S8000-05A
Applications	Suitable for use in Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended Dilution	Immunohistochemistry (paraffin and frozen sections): 1:400-1:800 using immunofluorescence microscopy, with overnight incubation at 4°C.
	Optimal dilutions to be determined by the researcher.
Positive Control	Frozen sections of rat colon.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Concentration	Not determined
Form	Supplied as a lyophilized powder. Reconstitute with 50-100 ul ddH2O or 40-50% glycerol for long-term storage. Dilute further in 0.1 M PBS with 1% BSA and 0.1% sodium azide.
Purity	Serum
Immunogen	Substance P conjugated to BSA
Specificity	Recognizes Substance P. Absorption with 10-100ug SP and NKA per ml diluted antiserum abolishes the staining while Neurokinin A does not. Species Crossreactivity: Human, porcine, rat, mouse.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.