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You are here:Home » Antibodies » Abs to Substance P » Anti -Substance P (NK, Neurokinin)

Anti -Substance P (NK, Neurokinin)

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Specifications

Clone Host Grade Applications
Polyclonal Guinea pig Serum IH IF
Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions. Substance P-containing tumors arising in the ileum are often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, bronchoconstriction and sudden drops in blood pressure. Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide.
Catalog #S8000-05B
ApplicationsSutiable for use in Immunofluorescence and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry: Frozen sections
Immunofluorescence: 1:400-1:800 with overnight incubation at 4°C.
Optimal dilutions to be determined by the researcher.
Positive ControlFrozen sections of rat colon
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGuinea pig
ConcentrationNot Determined
FormSupplied as a lyophilized powder. Reconstitute with 50ul sterile ddH2O. Dilute further with PBS, 1% BSA, 0.1% sodium azide.
PuritySerum
ImmunogenSubstance P conjugated to BSA.
SpecificityRecognizes Substance P. Absorption with 10-100ug SP and NKA per ml diluted antiserum abolishes the staining while GRP and NKB do not. Species Crossreactivity: human, rat, rabbit and fish (cod).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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