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Specifications

Clone Host Grade Applications Polyclonal Rabbit Serum IH IF

Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions. Substance P-containing tumors arising in the ileum are
often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, bronchoconstriction and sudden drops in blood pressure. Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide.
Catalog #	S8000-05B
Applications	Sutiable for use in Immunofluorescence and Immunohistochemistry (frozen sections)
Recommended Dilution	Immunohistochemistry: 1:400-1:800 using immunofluorescence microscopy, with overnight incubation at 2-8°C.
Positive Control	Frozen sections of rat colon.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Host	Rabbit
Concentration	Not determined
Form	Supplied as a liquid.
Purity	Serum
Immunogen	Substance P conjugated to BSA.
Specificity	Recognizes Substance P. Absorption with 10-100ug SP and NKA per ml diluted antiserum abolishes the staining while GRP and NKB do not. Species Crossreactivity: Human, rat, rabbit, fish (cod).
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.