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You are here:Home » Antibodies » Abs to Substance P » Anti -Substance P, aa4-11 (NK, Neurokinin)

Anti -Substance P, aa4-11 (NK, Neurokinin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH
Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions. Substance P-containing tumors arising in the ileum are
often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, bronchoconstriction and sudden drops in blood pressure. Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide.
Catalog #S8000-05D
ApplicationsSuitable for use in Immunohistochemistry (frozen and paraffin-embedded tissue, no proteolytic treatment required).
Recommended DilutionImmunohistochemistry: 1:400-1:800 using PAP, with overnight incubation at 2-8°C.
Positive ControlFrozen sections of rat colon.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
ConcentrationNot determined
FormSupplied as a liquid.
PuritySerum
ImmunogenSynthetic Substance P 4-11, conjugated to thyroglobulin using CDI.
SpecificityRecognizes Substance P. Absorption with 10-100ug SP 1-4 per ml diluted antiserum abolishes the staining. Species Crossreactivity: Human and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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