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You are here:Home » Antibodies » Abs to Substance P » Anti -Substance P (NK, Neurokinin)

Anti -Substance P (NK, Neurokinin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH RIA
Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapse. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
Catalog #S8000-11
ApplicationsSuitable for use in Immunohistochemistry and RIA. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Paraffin): 1:100. Antigen retrieval with Citrate pH 6.0 is recommended
RIA: 1:10,000. 80% binding detects ~5pg/ml.
Optimal dilutions to be determined by the researcher.
Recommended ControlSpinal Cord
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in 0.1% sodium azide.
PuritySerum
ImmunogenSubstance P (Accession# NP_003173)
SpecificityRecognizes human Substance P. Species Crossreactivity: rat and mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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