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You are here:Home » Antibodies » Abs to Substance P » Anti -Substance P Receptor (NK-1 Receptor)

Anti -Substance P Receptor (NK-1 Receptor)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH IC IF
The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma. Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).
Catalog #S8000-51B
ApplicationsSuitable for use in Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Frozen): 1:1000. Can also be used on fixed tissue sections. In immunohistochemical experiments, plasma membrane staining is observed.
Immunofluorescence (Immunocytochemistry): 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot Determined
FormSupplied as a liquid.
PuritySerum
ImmunogenSynthetic peptide corresponding to the C-terminus of rat the Substance P Receptor conjugated to bovine thyroglobulin. Species Sequence Homology: canine, 92%
SpecificityRecognizes the rat Substance P Receptor. Species Crossreactivity: mouse and guinea pig.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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