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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -SAE2 (SUMO-activating Enzyme Subunit 2, Anthracycline-associated Resistance ARX, Ubiquitin-like 1-activating Enzyme E1B, UBA2, UBLE1B, HRIHFB2115)

Anti -SAE2 (SUMO-activating Enzyme Subunit 2, Anthracycline-associated Resistance ARX,
Ubiquitin-like 1-activating Enzyme E1B, UBA2, UBLE1B, HRIHFB2115)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
Covalent attachment of one protein to another is one of the more prominent posttranslational modifications in respect to size and ubiquity. Ubiquitin is the most familiar of the protein modifiers and its activation and transfer to target proteins has been studied extensively. Recently, a new group of ubiquitin-like proteins has been receiving a lot of attention. SUMO, or Sentrin, is one of the most intriguing. SUMO has been implicated in the stabilization of target proteins and/or their localization to sub-cellular complexes. The conjugation of SUMO-1, SUMO-2 and SUMO-3 onto target proteins requires the concerted action of the specific E1-activating enzyme SAE1/SAE2, the E2-conjugating enzyme Ubc9, and an E3-like SUMO ligase.
Catalog #S8025-90L
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:16,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to ALSRGLPRELAEA-C, from SAE2, at N-terminal (NP_005490).
SpecificityRecognizes SAE2. Species sequence homology: Human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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