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You are here:Home » Antibodies » Abs to Superoxide Dismutase » Anti -Superoxide Dismutase, Mn (SOD Mn)

Anti -Superoxide Dismutase, Mn (SOD Mn)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells: extracellular SOD (EC SOD, SOD-3); copper and zinc-containing SOD (Cu/Zn SOD, SOD-1); and manganese-containing SOD (Mn SOD, SOD-2). Mn SOD is an 80kD homotetramer that contains Mn ions and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)-inducible enzyme that protects cells from TNF-mediated apoptosis via superoxide anion detoxification, and the subsequent regulation of apoptosis through cytochrome c release and modulation of the redox state of the mitochondria. Overexpression of this enzyme protects neurons from NMDA- and nitric oxide-induced neurotoxicity.
Catalog #S8060-10C
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsWestern Blot (Colorimetric): 1:1000
Optimal dilutions to be determined by researcher.
Positive ControlHuman skeletal muscle
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenHuman Superoxide Dismutase (Mn SOD) protein (NP_000627, P04179)
SpecificityRecognizes human Superoxide Dismutase (SOD) at~25kD. Species Crossreactivity: mouse, rat, bovine, canine, guinea pig, hamster, monkey, porcine, rabbit, sheep and Xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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