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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E B IH

Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide (1-4). There are three SOD isoenzymes in mammalian cells: extracellular SOD (EC SOD, SOD-3); copper and zinc-containing SOD (Cu/Zn SOD, SOD-1); and manganese-containing SOD (Mn SOD, SOD-2). Mn SOD is an 80kD homotetramer that contains Mn ions and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)-inducible enzyme that protects cells from TNF- mediated apoptosis (5) via superoxide anion detoxification, and the subsequent regulation of apoptosis through cytochrome c release and modulation of the redox state of the mitochondria (6). Overexpression of this enzyme protects neurons from NMDA- and nitric oxide-induced neurotoxicity (7).
Catalog #	S8060-10C
Applications	Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended Dilution	Optimal dilutions to be determined by researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Purity	Purified by Protein A affinity chromatography.
Immunogen	Human Superoxide Dismutase (Mn SOD).
Specificity	Recognizes human Superoxide Dismutase (SOD) at~25kD. Species Crossreactivity: mouse, rat, bovine, canine, guinea pig, hamster, monkey, porcine, rabbit, sheep and Xenopus.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.