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You are here:Home » Antibodies » Abs to Superoxide Dismutase » Anti -Superoxide Dismutase 3 (Superoxide Dismutase 3 Extracellular, SOD 3, SOD3, Extracellular Superoxide Dismutase [Cu Zn], Extracellular Superoxide Dismutase Precursor, EC SOD, MGC20077)

Anti -Superoxide Dismutase 3 (Superoxide Dismutase 3 Extracellular, SOD 3, SOD3,
Extracellular Superoxide Dismutase [Cu Zn], Extracellular Superoxide Dismutase Precursor,
EC SOD, MGC20077)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH
SOD3 is a member of the superoxide dismutase protein family. SODs are antioxidant enzymes that catalyse the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. SOD3 is thought to protect the brain, lungs and other tissues from oxidative stress. It is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A small percentage of SOD3 is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the extracellular matrix.
Catalog #S8060-10M
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:4000
Immunohistochemistry (Frozen/Paraffin): 1:100-1:2000
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder. Reconstitute with 100ul of sterile ddH2O.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa18-37, WTGEDSAEPNSDSAEWIRD, of human extracellular Superoxide Dismutase, conjugated to diphtheria toxin.
SpecificityRecognizes human extracellular superoxide dismutase. Stains prominently specific human airway (probably Clara cells) and alveolar type II cells and some tubular cells in the kidney.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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