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You are here:Home » Antibodies » Abs to Superoxide Dismutase » Anti -Superoxide Dismutase 3 (Superoxide Dismutase 3 Extracellular, SOD 3, SOD3, Extracellular Superoxide Dismutase [Cu Zn], Extracellular Superoxide Dismutase Precursor, EC SOD, MGC20077)

Anti -Superoxide Dismutase 3 (Superoxide Dismutase 3 Extracellular, SOD 3, SOD3,
Extracellular Superoxide Dismutase [Cu Zn], Extracellular Superoxide Dismutase Precursor,
EC SOD, MGC20077)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH
Catalog #S8060-10M
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. CATALYTIC ACTIVITY 2 superoxide + 2 H+ = O2 + H2O2. COFACTOR: Binds 1 copper ion per subunit. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Homotetramer.
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Cellular LocalizationSecreted protein; extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in quilibrium between the plasma and the endothelium.
Tissue SpecificityMajor SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid. POLYMORPHISM: The variant Gly-231 which is found in about 2.2% of individual displays a 10-fold increased plasma EC-SOD content due to reduced heparin-binding affinity and thus the impairment of its binding ability to endothelial cell surface. Belongs to the Cu-Zn superoxide dismutase family.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
PuritySerum
ImmunogenA synthetic peptide (WTGEDSAEPNSDSAEWIRD) corresponding to the amino acids 18-37 of human extracellular superoxide dismutase (SOD3) conjugated to diphtheria toxin has been used as the immunogen.
SpecificityThis antibody has been shown to be specific for extracellular superoxide dismutase (SOD3) protein. Species Crossreactivity: Human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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