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Specifications

Clone Host Grade Applications Monoclonal Mouse Ascites E B

Superoxide dismutase (SOD)is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu,Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu,Zn-SOD (EC-SOD/SOD-3). SOD1 isfound in all eukaryotic species as a homodimeric 32kD enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80kD tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to primary endogenous source of superoxide,the mitochondrial respiratory chain. SOD3 is aheparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways.SOD4 is a copper chaperone for superoxidedismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase.CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.
Catalog #	S8060-17A
Applications	Suitable for use in Immunoprecipitation. Other applications not tested.
Recommended Dilution	Western Blot: 1:200-1:1,000
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone Type	Monoclonal
Isotype	IgG1, k
Clone No	10K357
Host	Mouse
Source	Human
Concentration	Not determined
Form	Supplied as a liquid.
Purity	Ascites
Immunogen	Recombinant human protein purified from E.coli.
Specificity	Recognizes human Superoxide Dismutase 4.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.