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You are here:Home » Antibodies » Abs to Enzymes » Anti -Superoxide Dismutase, Mn (Manganese Superoxide Dismutase, Manganese SOD, Mn SOD, MnSOD, IPO-B, Superoxide Dismutase [Mn] Mitochondrial Precursor, Superoxide Dismutase 2 Mitochondrial, SOD 2, SOD2, SOD-2)

Anti -Superoxide Dismutase, Mn (Manganese Superoxide Dismutase, Manganese SOD, Mn SOD,
MnSOD, IPO-B, Superoxide Dismutase [Mn] Mitochondrial Precursor, Superoxide Dismutase 2
Mitochondrial, SOD 2, SOD2, SOD-2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IP IH FC IF
Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide (1, 2, 3). There are three SOD isoenzymes in mammalian cells. They are: extracellular SOD (EC SOD), copper and zinc-containing SOD (CuZn SOD) and manganese-containing SOD (Mn SOD, SOD-2). The CuZn form contains Cu and Zn ions and exists as a 32kD dimer in the cytosol. Mn SOD is an 80kD tetramer that contains Mn ion and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)-inducible enzyme that protects cells from NFmediated apoptosis (4) via superoxide anion detoxification and the subsequent regulation of apoptosis through cytochrome c release and the modulation of the redox state of the mitochondria (6). Mn SOD has also been shown to be a tumor suppressor in human breast cancer (7). Overexpression of this enzyme protects neurons from NMDAand nitric oxide-induced neurotoxicity.
Catalog #S8060-25E
ApplicationsSuitable for use in ELISA, Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry and Flow Cytometry. Other applications not tested.
Recommended DilutionWestern Blot: 0.1ug/ml. 1:2000.
Optimal dilutions to be determined by the researcher.
Positive ControlRat Brain Tissue Extract
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.0, 0.1% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenFull length Superoxide Dismutase protein (Rat). Cellular Localization: Mitochondrial matrix.
SpecificityRecognizes rat Superoxide Dismutase. Detects a band at ~25kDa. Species Crossreactivity: human, mouse, Xenopus laevis, bovine, chicken, canine, Drosophilia melanogaster, guinea pig, hamster, monkey, porcine, rabbit, sheep.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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