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You are here:Home » Antibodies » Abs to Superoxide Dismutase » Anti -SOD1 (Superoxide Dismutase [Cu-Zn], Superoxide Dismutase 1, hSod1)

Anti -SOD1 (Superoxide Dismutase [Cu-Zn], Superoxide Dismutase 1, hSod1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IH
Superoxide dismutase (SOD)is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu,Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu,Zn-SOD (EC-SOD/SOD-3). SOD1 isfound in all eukaryotic species as a homodimeric 32kD enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80kD tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to primary endogenous source of superoxide,the mitochondrial respiratory chain. SOD3 is aheparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways.SOD4 is a copper chaperone for superoxidedismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase.CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.
Catalog #S8060-33C
ApplicationsSuitable for use in Immunohistochemistry and ELISA Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 15ug/ml
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2F5
HostMouse
SourceBovine
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide, 0.1% BSA.
PurityPurified by Protein G affinity chromatography.
ImmunogenNative bovine SOD1.
SpecificityRecognizes bovine SOD1. Species sequence homology: human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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