Anti -Survival of Motor Neuron 1, Telomeric (Survival of Motor Neuron 1 (Telomeric), SMNT,
Survival of Motor Neuron 1, Survival Motor Neuron 1 Protein, SMN1, BCD541, Component of
Gems 1, Gemin 1, Gemin-1, SMA, SMA@, SMA1, SMA2, SMA3, SMA4, SMNC, Survival Motor
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
E B IP IF |
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| Survival of Motor Neuron 1 (SMN, Germin 1) is the central component of a large oligomeric complex (SMN complex), including Gemins 2-7, that is necessary and sufficient for the in vivo assembly of Sm proteins onto the small nuclear (sn)RNAs that mediate pre-mRNA splicing. The SMN complex is found in the cytoplasm and nucleus. Within the nucleus, this protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). Spinal muscular atrophy, a motor neuron disorder, results from reduced levels or a mutation in the Gemin 1 protein. | | | Catalog # | S8495-03 | | Applications | Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunofluorescence. Other applications not tested. | | Recommended Dilution | Western Blot: 1-2ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | A-431 Whole Cell Lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9E762 | | Host | Mouse | | Source | Human | | Concentration | ~2mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide. | | Purity | Purified | | Immunogen | Recombinant corresponding to human Survival of Motor Neuron 1, Telomeric. Cellular Localization: Cytoplasmic, nuclear | | Specificity | Recognizes human Survival of Motor Neuron 1, Telomeric at ~35kD. Species Crossreactivity: Mouse, Xenopus laevis | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Survival of Motor Neuron 1, Telomeric (Survival of Motor Neuron 1 (Telomeric), SMNT, Survival of Motor Neuron 1, Survival Motor Neuron 1 Protein, SMN1, BCD541, Component of Gems 1, Gemin 1, Gemin-1, SMA, SMA@, SMA1, SMA2, SMA3, SMA4, SMNC, Survival Motor |
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