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You are here:Home » Antibodies » Abs to Apoptosis » Anti -Survivin

Anti -Survivin

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH IC IF
Regulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. Inhibitor of Apoptosis (IAP) proteins contain one/three Cys/His baculovirus IAP repeats plus a C-terminus RING finger and are thought to block an evolutionary conserved step in apoptosis. Survivin encodes a structurally unique IAP. Present during fetal development, survivin is undetectable in terminally differentiated adult tissues. However, survivin becomes prominently expressed in transformed cell lines and in all the most common human cancers of lung, colon, pancreas, prostate and breast in vivo. Survivin is also found in high-grade non-Hodgkin’s lymphomas. These data suggest that apoptosis inhibition may be a general feature of neoplasia and identify survivin as a potential new target for apoptosis-based therapy in cancer and lymphoma.
Catalog #S8500-03G
ApplicationsSuitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry and Immunofluorescence. Other applications have not been tested.
Recommended DilutionImmunohistochemistry: Paraffin sections
Optimal dilutions to be determined by the researcher.
Positive ControlHeLa whole cell extract
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No3H1
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid, PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant human survivin, full-length. Epitope
SpecificityRecognizes the cytoplasmic form of human survivin (~16.5kD). Species Crossreactivity: rat, mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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