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Specifications

Clone Host Grade Applications Monoclonal Rabbit Supernatant E B IP IH IC FC

Survivin is a unique member of the inhibitor of apoptosis (IAP) protein family that interferes with post-mitochondrial events including activation of caspases. Survivin regulates cell cycle and is expressed in most tumors, but it is barely detectable in the terminally differentiated normal cells and tissues. The differential expression of survivin in cancer versus normal tissues makes it a useful tool in cancer diagnosis and a promising therapeutic target. Survivin is expressed in the G2/M phase of the cell cycle. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosi.
Catalog #	S8500-08
Applications	Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended Dilutions	Flow Cytometry: 1:120
	Western Blot: 1:1000-1:10,000
	Immunoprecipitation: 1:10
	Immunohistochemistry: 1:100-1:250
	Immunocytochemistry: 1:100-1:250
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG
Clone No	9E571
Host	Rabbit
Source	Human
Concentration	Not Determined
Form	Supplied as a liquid in buffer, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
Purity	Supernatant
Immunogen	Synthetic peptide corresponding to residues on the N-terminus of human Survivin.
Specificity	Recognizes human Survivin at ~16kD.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	Apoptosis inhibitor survivin, Apoptosis inhibitor 4