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Abs to Tyrosine Kinases
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Anti -SYK (Spleen Tyrosine Kinase, HGNC:11491, p72Syk, Tyrosine Protein Kinase SYK)
Anti -SYK (Spleen Tyrosine Kinase, HGNC:11491, p72Syk, Tyrosine Protein Kinase SYK)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IP |
|
| SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions. | | | Catalog # | S9100-01H1 | | Applications | Suitable for use in Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in Tris-citrate/phosphate buffer, pH 7-8, 0.09% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | The epitope recognized maps to a region between residues 250 and 300 of human Spleen Tyrosine Kinase using the numbering given in entry NP_003168.2 (GeneID 6850). | | Specificity | Species Crossreactivity: This antibody crossreacts with human. Other species have not been tested. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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