Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -SYK (Spleen Tyrosine Kinase, HGNC:11491, p72Syk, Tyrosine Protein Kinase SYK)

Anti -SYK (Spleen Tyrosine Kinase, HGNC:11491, p72Syk, Tyrosine Protein Kinase SYK)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
SYK is a 70kD non-receptor protein tyrosine kinase whose role differs in hematopoietic and non hematopoietic stem cells. In hematopoietic cells SYK is involved in the proximal signalling downstream of activated immunoreceptors (BCR, TCR, Fc receptors), thereby orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis. In epithelial cells SYK appears to function as a negative regulator of related events. Furthermore, SYK has been shown to promote expression or secretion of inflammation-related molecules in lung epithelial cells. SYK appears to be required for vascular integrity during development, thus, manipulation of SYK function in endothelial cells could potentially modulate tumor-associated angiogenesis. SYK also has been shown to interact with Epstein-Barr virus LMP2A.
Catalog #S9100-01P
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:16,000
Western Blot: 1-3ug/ml detects a band of ~70kDa in human bone marrow, lymph node and spleen lysates.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH 7.3, 0.02% sodium azide, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenPeptide with sequence C-KYLQQNRHVKDKN from the internal region of the SYK sequence.
SpecificityRecognizes an epitope within the internal region of human Spleen Tyrosine Kinase. Species sequence homology: mouse, canine, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links