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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -SYK, phosphorylated (Tyr525/526) (Tyrosine-protein Kinase SYK, Spleen Tyrosine Kinase)

Anti -SYK, phosphorylated (Tyr525/526) (Tyrosine-protein Kinase SYK, Spleen Tyrosine
Kinase)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Syk is a positive effector of BCR-stimulated responses. This protein couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.
Catalog #S9100-01U
ApplicationsSuitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to amino acid residues surrounding Tyr525/526 of human Syk (KLH).
SpecificityRecognizes human Syk when phosphorylated at Tyr525 and 526.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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